Association of Procollagen Type III N-terminal Peptide with Age and Mortality
Author Information
Author(s): Cvejkus Ryan, Wojczynski Mary, Jin Shiow, Thyagarajan Bharat, Zmuda Joseph
Hypothesis
Is there an association between baseline plasma P3NP concentration and risk of all-cause mortality?
Conclusion
Higher levels of P3NP are linked to increased mortality risk, particularly in women.
Supporting Evidence
- P3NP is a biomarker of fibrosis in several organs.
- A 1 SD higher P3NP level was associated with an 18% increased risk of mortality.
- The association was stronger in women compared to men.
Takeaway
If you have more of a certain protein in your blood, it might mean you're at a higher risk of not living as long, especially for women.
Methodology
Measured baseline plasma P3NP concentration and calculated mortality risk using Cox Proportional Hazards models.
Potential Biases
Potential biases related to self-reported health behaviors and chronic diseases.
Limitations
The study may not account for all potential confounding factors.
Participant Demographics
Men and women aged 32 to 110 years, with a mean age of 69.9 years.
Statistical Information
P-Value
1.18
Confidence Interval
1.10 - 1.26
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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