RIG-I Is Required for the Inhibition of Measles Virus by Retinoids
2011
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids
publication
Evidence: high
Author Information
Author(s): Soye Kaitlin J., Trottier Claire, Richardson Chris D., Ward Brian J., Miller Wilson H. Jr.
Primary Institution: McGill University Health Center Research Institute
Hypothesis
RIG-I is central to retinoid-mediated inhibition of MeV in vitro.
Conclusion
RIG-I expression is regulated by ATRA during MeV infection and is required for the anti-MeV state.
Supporting Evidence
- Vitamin A can significantly decrease measles-associated morbidity and mortality.
- Retinoid-induced gene I (RIG-I) expression is induced by retinoids and is important for IFN signaling.
- RIG-I is required for the retinoid-MeV antiviral response.
Takeaway
This study shows that a substance called retinoic acid helps the immune system fight off the measles virus by boosting a specific protein called RIG-I.
Methodology
The study used various cell lines to investigate the effects of retinoic acid and measles virus on RIG-I expression and its role in antiviral responses.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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