Recurrence Patterns in Head and Neck Cancer After Radiotherapy
Author Information
Author(s): Didem C Oksuz, Robin J Prestwich, Brendan Carey, Stuart Wilson, Mustafa S Senocak, Ananya Choudhury, Karen Dyker, Catherine Coyle, Mehmet Sen
Primary Institution: St James's Institute of Oncology, Leeds, UK
Hypothesis
To establish recurrence patterns among locally advanced head and neck non-nasopharyngeal squamous cell carcinoma (HNSCC) patients treated with radical (chemo-) radiotherapy.
Conclusion
The majority of failures following non-surgical treatment for locally advanced HNSCC were loco-regional, within the radiotherapy target volume.
Supporting Evidence
- 82.8% of patients achieved a complete response to treatment.
- 3-year cause-specific survival was 66.8%.
- Among complete responders, 3-year local and regional control rates were 86.8% and 89.5%, respectively.
Takeaway
This study looked at patients with throat cancer who got radiation treatment and found that most of them had their cancer come back in the same area where it was treated.
Methodology
151 patients were treated with radical three-dimensional conformal radiotherapy and their recurrence patterns were analyzed.
Potential Biases
Potential biases in treatment assignment and patient follow-up.
Limitations
The study is retrospective and may have biases related to patient selection and treatment variations.
Participant Demographics
Median age was 59 years, with 72% male and a mix of stages III and IV disease.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website