Wnt-c59 Improves Heart Function in Mice with Heart Failure
Author Information
Author(s): Paul Mhairi A., Wainwright Cherry L., Hector Emma E., Ryberg Erik, Leslie Stephen J., Walsh Sarah K.
Primary Institution: Robert Gordon University
Hypothesis
Does the PORCN inhibitor Wnt-c59 improve structural and functional features in a mouse model of heart failure with preserved ejection fraction (HFpEF)?
Conclusion
Short-term treatment with Wnt-c59 improves both the structural and functional features of experimental HFpEF in mice.
Supporting Evidence
- Wnt-c59 treatment reduced end diastolic pressure in HFpEF mice.
- Wnt-c59 increased the expression of brain natriuretic peptide in the heart.
- Wnt-c59 improved the collagen type ratio in the heart.
Takeaway
Researchers gave a special medicine called Wnt-c59 to mice with heart problems, and it helped their hearts work better and feel less stiff.
Methodology
Male mice were fed a high-fat diet and treated with L-NAME for 5 weeks, followed by 2 weeks of Wnt-c59 administration.
Potential Biases
Potential bias due to the use of a single sex in the study.
Limitations
The study was conducted only in male mice, which may limit the generalizability of the findings.
Participant Demographics
Male C57Bl/6J mice, 8 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website