Effect of Antibiotic Exposure on Pseudomonas aeruginosa Survival
Author Information
Author(s): I. J. Clifton, Denton M., M'Zali F., Peckham D. G.
Primary Institution: Regional Adult Cystic Fibrosis Unit, St James University Hospital, Leeds, UK
Hypothesis
Do strains of Pseudomonas aeruginosa show differences in resistance to desiccation and is this affected by preincubation in sub-MICs of β-lactam antibiotics?
Conclusion
The mucoid phenotype of Pseudomonas aeruginosa enhances its resistance to desiccation, and preincubation with certain antibiotics can significantly affect this resistance.
Supporting Evidence
- The mucoid phenotype promoted desiccation survival.
- Preincubation with meropenem reduced desiccation resistance.
- Ceftazidime had less effect on the strains studied.
Takeaway
Some bacteria can survive without water for a long time, and a special coating helps them stay alive. Using certain medicines can change how well they survive.
Methodology
The study used a desiccation survival model and compared the effects of preincubation with antibiotics on different strains of Pseudomonas aeruginosa.
Limitations
The study may not account for all environmental factors affecting bacterial survival.
Participant Demographics
Strains obtained from clinical samples of sputa from people with cystic fibrosis.
Statistical Information
P-Value
P = 0.006; P = 0.0476; P < 0.0001; P = 0.0002; P = 0.0143
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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