RANTES Gene and SARS Risk
Author Information
Author(s): Ng Man Wai, Zhou Gangqiao, Chong Wai Po, Lee Loretta Wing Yan, Law Helen Ka Wai, Zhang Hongxing, Wong Wilfred Hing Sang, Fok Susanna Fung Shan, Zhai Yun, Yung Raymond WH, Chow Eudora Y, Au Ka Leung, Chan Eric YT, Lim Wilina, Peiris JS Malik, He Fuchu, Lau Yu Lung
Primary Institution: The University of Hong Kong
Hypothesis
The polymorphisms of RANTES, IP-10, and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
Conclusion
The RANTES -28 G allele plays a role in the pathogenesis of SARS.
Supporting Evidence
- RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese.
- Individuals with RANTES -28 CG and GG genotypes had a significantly increased risk of developing SARS.
- The -28 G allele conferred risk of death in a gene-dosage dependent manner.
Takeaway
This study found that a specific gene variant (RANTES -28 G allele) can make people more likely to get severe acute respiratory syndrome (SARS) and even die from it.
Methodology
The study tested the polymorphisms of RANTES, IP-10, and Mig in SARS patients and controls using logistic regression.
Limitations
The association of RANTES -28 G allele with SARS susceptibility was not observed in Beijing Chinese patients.
Participant Demographics
495 Hong Kong Chinese SARS patients (mean age 40.74 years, 211 males and 284 females) and 578 controls (mean age 30.05 years, 343 males and 235 females).
Statistical Information
P-Value
p<0.0001
Confidence Interval
95%CI: 2.11–3.71
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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