Brachytherapy vs. Radical Hysterectomy for Cervical Cancer
Author Information
Author(s): Cetina Lucely, Garcia-Arias Alicia, Candelaria Myrna, Cantú David, Rivera Lesbia, Coronel Jaime, Bazan-Perkins Blanca, Flores Vladimir, Gonzalez Aaron, Dueñas-González Alfonso
Primary Institution: Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Hypothesis
Can radical hysterectomy after external beam chemoradiation provide similar survival outcomes as brachytherapy in cervical cancer patients?
Conclusion
Radical hysterectomy can be performed after external beam chemoradiation without compromising survival in cervical cancer patients when brachytherapy is not available.
Supporting Evidence
- Both treatment groups had similar clinicopathological characteristics.
- The median follow-up was 26 months for surgery and 22 months for standard therapy.
- Eight patients in each group experienced recurrence and died.
Takeaway
Doctors compared two treatments for cervical cancer: one group had surgery after radiation, and the other had radiation with a special type of treatment called brachytherapy. Both groups did equally well.
Methodology
This was a non-randomized matched comparison of 80 cervical cancer patients treated with either external beam chemoradiation followed by brachytherapy or radical hysterectomy.
Potential Biases
Potential biases due to non-randomized design and matching process.
Limitations
The study is non-randomized, which may introduce biases in patient selection.
Participant Demographics
Patients were matched by age, FIGO stage, and histology, with a median age of 45 years.
Statistical Information
P-Value
p<0.016 for hydronephrosis, p<0.008 for proctitis
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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