Creatinine-to-Cystatin C Ratio and Frailty
Author Information
Author(s): Jia Shuli, Ge Mei-Ling, Xue Qian-Li, Dong Bigrong
Primary Institution: West China Hospital, Sichuan University
Hypothesis
The study aimed to investigate the association between creatinine-to-cystatin C ratio and frailty, as well as the mediating role of muscle strength.
Conclusion
Higher creatinine-to-cystatin C ratio is associated with a lower risk of frailty, and muscle strength partially mediates this relationship.
Supporting Evidence
- Higher CCR was associated with lower risk of frailty.
- The relationship between CCR and frailty was not significant when adding muscle strength.
- The association between baseline CCR and incident frailty was partially mediated by muscle strength.
Takeaway
This study found that a higher ratio of creatinine to cystatin C can mean less frailty in older adults, and having stronger muscles helps explain this.
Methodology
Cross-sectional and longitudinal analyses with 4-year follow-up of community-dwelling adults aged ≥60 years.
Limitations
The study may not be generalizable beyond the Chinese population.
Participant Demographics
Community-dwelling adults aged ≥60 years.
Statistical Information
P-Value
p=0.030
Confidence Interval
(0.18, 0.92)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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