Epithelial-Mesenchymal Transition in Tumor Microenvironment
Author Information
Author(s): Jing Yingying, Han Zhipeng, Zhang Shanshan, Liu Yan, Wei Lixin
Primary Institution: Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, China
Hypothesis
The tumor microenvironment plays a crucial role in facilitating cancer metastasis and may induce the occurrence of EMT in tumor cells.
Conclusion
The study highlights the complex interactions between the tumor microenvironment and epithelial-mesenchymal transition (EMT) in cancer progression.
Supporting Evidence
- EMT is crucial for tumor invasion and metastasis.
- Inflammatory cells and hypoxia in the tumor microenvironment can induce EMT.
- TGF-β is a significant inducer of EMT in cancer progression.
- Hypoxia and oxidative stress are linked to the initiation of EMT.
- CSCs may acquire stem cell-like properties through EMT.
Takeaway
This study explains how the environment around tumors can change cancer cells, making them more likely to spread in the body.
Methodology
The review summarizes current knowledge about the role of the tumor microenvironment in EMT and the related signaling pathways.
Limitations
The study acknowledges that many unknown factors and intracellular signaling pathways are associated with EMT.
Digital Object Identifier (DOI)
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