MicroRNA-183 Family and Lung Cancer
Author Information
Author(s): Zhu Wangyu, Liu XiaoGuang, He JianYing, Chen DongDong, Hunag YanYan, Zhang Yong Kui
Primary Institution: Zhoushan Hospital of Zhejiang Province
Hypothesis
The study aims to identify specific microRNAs with diagnostic and prognostic value for lung cancer patients.
Conclusion
The expressions of miR-96, miR-182, and miR-183 in tumor and serum samples may serve as potential biomarkers for lung cancer diagnosis and prognosis.
Supporting Evidence
- High expression of miR-96, miR-182, and miR-183 was found in lung cancer tissues compared to normal tissues.
- Patients with high levels of these microRNAs had shorter overall survival.
- The study identified a correlation between serum and tumor levels of miR-96.
Takeaway
This study found that certain tiny molecules in the body, called microRNAs, can help doctors tell if someone has lung cancer and how serious it is.
Methodology
The study examined gene expression of the miR-183 family in 70 paired samples from lung cancer patients and 44 serum samples from normal volunteers using RT-qPCR.
Potential Biases
Potential bias due to the selection of patients and the exclusion of those with mixed histology or insufficient tumor material.
Limitations
The study only included patients who had not received preoperative treatment and may not represent all lung cancer patients.
Participant Demographics
{"mean_age":{"<60":34,"≥60":36},"sex":{"male":56,"female":14},"smoking":{"nonsmokers":24,"current_smokers":46}}
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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