Surgery Improves Survival in Multiple Myeloma Bone Disease
Author Information
Author(s): Shi Xiangjun, Yao Xingchen, Wu Yue, Du Boran, Du Xinru
Primary Institution: Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Hypothesis
Does surgical intervention improve survival rates in patients with multiple myeloma bone disease compared to those who do not undergo surgery?
Conclusion
Surgery combined with chemotherapy significantly improves survival rates for patients with multiple myeloma bone disease compared to chemotherapy alone.
Supporting Evidence
- Patients who underwent surgery had a median overall survival of 86 months compared to 37 months for those who did not.
- The 5-year survival rate was 31.8% for surgical patients versus 17.3% for non-surgical patients.
- Surgical intervention significantly improved patient survival rates and quality of life.
Takeaway
If someone with multiple myeloma has surgery, they might live longer than if they only get chemotherapy.
Methodology
A retrospective review of 325 patients with multiple myeloma, comparing 135 who underwent surgery to 190 who did not.
Limitations
The study is retrospective with a small sample size and lacks performance status and high-risk chromosome information.
Participant Demographics
Of the 135 patients who underwent surgery, 61% were male and 39% were female.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website