Candidate Genes for Day Blindness in Dachshunds
Author Information
Author(s): Wiik Anne Caroline, Ropstad Ernst-Otto, Bjerkås Ellen, Lingaas Frode
Primary Institution: Norwegian School of Veterinary Science
Hypothesis
Which candidate genes are associated with day blindness in the standard wire haired dachshund?
Conclusion
All ten candidate genes were excluded as causal for early onset cone-rod dystrophy in the standard wire haired dachshund.
Supporting Evidence
- Three genes involved in cone degeneration were studied.
- Seven genes associated with cone-rod dystrophies were also evaluated.
- A high frequency of recombinations was found between candidate marker alleles and the disease.
Takeaway
The study looked for genes that might cause day blindness in dachshunds but found that none of the ten genes studied were responsible.
Methodology
The study evaluated ten candidate genes in a family of 36 informative offspring to identify associations with day blindness.
Limitations
The study only examined a limited number of candidate genes and may not account for other genetic factors.
Participant Demographics
The study involved a family of standard wire haired dachshunds, including affected and unaffected offspring.
Digital Object Identifier (DOI)
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