ICOS Gene Polymorphisms and Breast Cancer Risk
Author Information
Author(s): Xu Fengyan, Li Dalin, Zhang Qiujin, Fu Zhenkun, Zhang Jie, Yuan Weiguang, Chen Shuang, Pang Da, Li Dianjun
Primary Institution: Harbin Medical University
Hypothesis
Are single nucleotide polymorphisms (SNPs) in the ICOS gene associated with sporadic breast cancer susceptibility and progression in Chinese women?
Conclusion
ICOS gene polymorphisms may affect the risk of breast cancer and are associated with breast cancer characteristics in a northern Chinese population.
Supporting Evidence
- The CT genotype and C allele of rs10932029 were associated with an increased risk of breast cancer.
- The associations were replicated in an independent validation cohort.
- Certain haplotypes were found to be more common in breast cancer cases than in controls.
Takeaway
This study found that certain changes in the ICOS gene can make women more likely to get breast cancer.
Methodology
The study genotyped five SNPs in the ICOS gene among 609 breast cancer patients and 665 healthy controls, with replication in an independent cohort.
Limitations
The study is limited to a specific population in northeast China, which may affect the generalizability of the results.
Participant Demographics
The study included 609 breast cancer patients and 665 age-matched healthy controls, all from Heilongjiang Province, China.
Statistical Information
P-Value
0.030
Confidence Interval
95% CI 1.037-2.077
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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