P-glycoprotein Expression in Bone Marrow
Author Information
Author(s): S. Hegewisch-Becker, M. Fliegner, T. Tsuruo, A. Zander, W. Zeller, D.K. Hossfeld
Primary Institution: Medical University Clinic of Hamburg
Hypothesis
Can P-glycoprotein expression be found in normal and reactive bone marrows?
Conclusion
P-glycoprotein expression was found in a significant proportion of normal and reactive bone marrow samples.
Supporting Evidence
- 27 of 53 samples were positive for P-glycoprotein expression.
- 5 of 23 normal samples and 13 of 28 reactive samples were positive for P-glycoprotein.
- The percentage of positive cells ranged from 2% to 80%.
Takeaway
The study looked at how a protein called P-glycoprotein is found in bone marrow, and it turns out that many samples had this protein, even in healthy people.
Methodology
Immunocytochemistry and PCR were used to detect P-glycoprotein expression in bone marrow samples.
Limitations
The study had a small sample size and did not explore lineage specificity of P-gp expression.
Participant Demographics
26 men and 27 women, ages ranged from 15 to 87 with a mean age of 48 years.
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