Distinct Tumor Induction by MMTV-Wnt1 and MMTV-ΔN89β-Catenin in Mammary Glands
Author Information
Author(s): Brigitte Teissedre, Alicia Pinderhughes, Angela Incassati, Sarah J. Hiremath, Minoti Cowin
Primary Institution: New York University School of Medicine
Hypothesis
MMTV-Wnt1 and MMTV-ΔN89β-catenin induce tumors with different phenotypes and activate canonical signaling in distinct progenitor cell types.
Conclusion
The study shows that MMTV-Wnt1 and MMTV-ΔN89β-catenin induce distinct tumors and activate different signaling pathways in mammary progenitor cells.
Supporting Evidence
- MMTV-Wnt1 and MMTV-ΔN89β-catenin induce tumors with different cellular compositions.
- MMTV-Wnt1 activates Hedgehog signaling in the tumor microenvironment.
- Distinct progenitor cell types respond differently to Wnt signaling.
Takeaway
This research found that two types of genes can cause breast tumors in mice, but they do it in different ways and affect different types of cells.
Methodology
The study used mouse models to analyze the effects of MMTV-Wnt1 and MMTV-ΔN89β-catenin on mammary gland development and tumor formation, employing various reporter genes to assess signaling pathways.
Limitations
The study is limited to mouse models, which may not fully replicate human breast cancer biology.
Digital Object Identifier (DOI)
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