Effects of Harmine and Imipramine on Brain Energy Metabolism
Author Information
Author(s): Gislaine Z. Réus, Roberto B. Stringari, Cinara L. Gonçalves, Giselli Scaini, Milena Carvalho-Silva, Gabriela C. Jeremias, Isabela C. Jeremias, Gabriela K. Ferreira, Emílio L. Streck, Jaime E. Hallak, Antônio W. Zuardi, José A. Crippa, João Quevedo
Primary Institution: Universidade do Extremo Sul Catarinense
Hypothesis
The study aims to assess the effects induced by acute and chronic administration of harmine and imipramine on energy metabolism in the rat brain.
Conclusion
The study found that both harmine and imipramine alter mitochondrial respiratory chain and creatine kinase activities in the rat brain, suggesting their involvement in energy metabolism.
Supporting Evidence
- Acute treatment with harmine and imipramine increased creatine kinase activity in the prefrontal cortex.
- Chronic treatment with imipramine and harmine also increased creatine kinase activity in the striatum.
- Harmine at certain doses decreased creatine kinase activity in the striatum.
- Mitochondrial respiratory chain complex activities were altered by both drugs depending on the treatment and dosage.
Takeaway
Researchers gave rats two different drugs to see how they affect energy in the brain, and they found that both drugs changed how the brain uses energy.
Methodology
The study involved administering harmine and imipramine to rats and measuring the activities of creatine kinase and mitochondrial respiratory chain complexes in the brain.
Limitations
The study was conducted on rats, which may not fully represent human physiology.
Participant Demographics
Male Adult Wistar rats, 60 days old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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