Identifying Genes Linked to Breast Cancer Progression
Author Information
Author(s): Kurisetty Vittal V, Johnston Patrick G, Rudland Philip S, El-Tanani Mohamed K
Primary Institution: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast
Hypothesis
How does osteopontin influence gene expression related to breast cancer malignancy?
Conclusion
The study suggests that osteopontin may enhance malignant properties in breast cancer cells through the overexpression of certain genes.
Supporting Evidence
- Osteopontin is linked to increased malignancy in breast cancer.
- The study identified 982 expressed sequence tags (ESTs) and 659 known genes.
- RAN GTPase was found to be one of the most differentially expressed genes.
Takeaway
This study looked at how a protein called osteopontin affects genes in breast cancer cells, helping us understand why some cells become more aggressive.
Methodology
The study used suppressive subtractive hybridization to evaluate gene expression differences between benign and malignant rat mammary cell lines.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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