Resveratrol and Pancreatic Cancer
Author Information
Author(s): Roy Sanjit K. Chen, Qinghe Fu, Junsheng Shankar, Sharmila Srivastava, Rakesh K. Srivastava
Primary Institution: The University of Kansas Cancer Center
Hypothesis
Does resveratrol regulate antitumor activities of FOXO transcription factors in pancreatic cancer cells?
Conclusion
Resveratrol inhibits pancreatic tumor growth by activating FOXO transcription factors through the inhibition of ERK and AKT pathways.
Supporting Evidence
- Resveratrol inhibited cell viability and colony formation in pancreatic cancer cell lines.
- It induced apoptosis through caspase-3 activation.
- Resveratrol treatment resulted in significant tumor growth inhibition in mice.
- The study demonstrated that FOXO transcription factors are crucial for resveratrol's effects.
Takeaway
Resveratrol is a natural compound that helps stop pancreatic cancer cells from growing by making certain proteins work better.
Methodology
Pancreatic cancer cell lines were treated with resveratrol, and various assays were conducted to measure cell viability, apoptosis, and gene expression.
Potential Biases
Potential bias in the selection of cell lines and animal models used.
Limitations
The study primarily focuses on in vitro and in vivo models, which may not fully replicate human responses.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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