The Neuropharmacology of (-)-Stepholidine and its Potential Applications
2007

The Neuropharmacology of (-)-Stepholidine and its Potential Applications

publication Evidence: moderate

Author Information

Author(s): Yang Kechun, Jin Guozhang, Wu Jie

Primary Institution: Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA

Hypothesis

SPD can effectively restore previously imbalanced functional linkage between D1 and D2 receptors under schizophrenic conditions.

Conclusion

SPD is a novel, natural compound with potentially therapeutic roles in the treatment of schizophrenia and Parkinson's disease.

Supporting Evidence

  • SPD improves both the negative and positive symptoms of schizophrenia.
  • SPD relieves the motor symptoms of Parkinson’s disease when co-administered with Levodopa.
  • SPD exhibits neuroprotective effects through an antioxidative mechanism.

Takeaway

SPD is a natural substance that can help treat mental health issues like schizophrenia and movement problems like Parkinson's disease by balancing certain brain chemicals.

Methodology

The review discusses various studies on SPD's effects on dopamine receptors and its potential therapeutic applications.

Digital Object Identifier (DOI)

10.2174/157015907782793649

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