Insulin Treatment Reduces Inflammation After Meals in Type 2 Diabetes
Author Information
Author(s): Beisswenger P J, Brown W V, Ceriello A, Le N A, Goldberg R B, Cooke J P, Robbins D C, Sarwat S, Yuan H, Jones C A, Tan M H
Primary Institution: Dartmouth Medical School and Dartmouth-Hitchcock Medical Center
Hypothesis
Controlling post-meal hyperglycaemia with a prandial + basal insulin regimen can attenuate meal-induced increases of inflammatory cytokines.
Conclusion
Using prandial + basal insulin helps lower inflammation after meals in patients with Type 2 diabetes compared to just basal insulin.
Supporting Evidence
- Prandial + basal insulin resulted in lower post-meal glucose levels.
- Inflammatory markers like hsCRP, TNF-α, and interleukin-6 were significantly lower in the prandial + basal group.
- Post-meal glucose levels correlated with inflammatory biomarker levels.
- Patients on prandial + basal insulin had higher insulin levels after meals.
Takeaway
This study shows that giving insulin before meals can help keep blood sugar down and reduce inflammation in people with diabetes.
Methodology
Patients were given either prandial + basal insulin or basal insulin for 24 weeks, and their blood was tested after a mixed-meal breakfast.
Potential Biases
Potential bias due to differences in patient demographics and treatment adherence.
Limitations
The study had a modest sample size and a difference in age between treatment groups.
Participant Demographics
Patients aged 35-75 years with Type 2 diabetes, mostly male, with a mix of ethnic backgrounds.
Statistical Information
P-Value
< 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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