MicroRNA Predictors of Longevity in Caenorhabditis elegans
2011
MicroRNA Predictors of Longevity in C. elegans
Sample size: 463
publication
10 minutes
Evidence: high
Author Information
Author(s): Pincus Zachary, Smith-Vikos Thalyana, Slack Frank J.
Primary Institution: Yale University
Hypothesis
Can early-life gene expression states predict future longevity in C. elegans?
Conclusion
The study identifies specific microRNAs that can predict lifespan variability in C. elegans.
Supporting Evidence
- Early-to-mid-adulthood measures of homeostatic ability predict 62% of longevity variability.
- Three microRNAs were identified that predict up to 47% of lifespan differences.
- Fluctuations in early-life insulin signaling may determine individual lifespan.
Takeaway
Some tiny molecules in worms can tell us how long they might live, even when they are young.
Methodology
The researchers observed individual C. elegans in a controlled environment and measured various biomarkers throughout their lives.
Limitations
The study primarily focuses on a single species and may not generalize to other organisms.
Participant Demographics
The study involved genetically identical C. elegans reared in controlled environments.
Statistical Information
P-Value
p<10−33
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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