HIV Nuclear Entry: Clearing the Fog
2010
Understanding HIV Nuclear Entry
Commentary
Evidence: moderate
Author Information
Author(s): Vaibhav B. Shah, Christopher Aiken
Primary Institution: Vanderbilt University School of Medicine
Hypothesis
How does the HIV-1 capsid facilitate nuclear entry in nondividing cells?
Conclusion
The study highlights the role of the HIV-1 capsid in nuclear entry and its interaction with host factors.
Supporting Evidence
- HIV-1 can infect nondividing cells, unlike most other retroviruses.
- The capsid protein is crucial for HIV-1's ability to enter the nucleus.
- CPSF6-358 inhibits HIV-1 at an early step in infection.
- Mutations in the capsid protein can affect HIV-1's dependence on host factors.
Takeaway
HIV-1 can sneak into cells that aren't dividing, and scientists are figuring out how it does that using a special part of the virus called the capsid.
Limitations
The study does not fully explore the role of uncoating in nuclear entry.
Digital Object Identifier (DOI)
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