Role of CD151/Integrin β1 Complex in Hepatocellular Carcinoma Progression
Author Information
Author(s): Devbhandari Ranjan Prasad, Shi Guo-Ming, Ke Ai-Wu, Wu Fei-Zhen, Huang Xiao-Yong, Wang Xiao-Ying, Shi Ying-Hong, Ding Zhen-Bin, Xu Yang, Dai Zhi, Fan Jia, Zhou Jian
Primary Institution: Liver Cancer Institute, Shanghai Medical School, Fudan University
Hypothesis
The study investigates the role of the CD151/integrin β1 complex in the progression of hepatocellular carcinoma (HCC).
Conclusion
CD151 plays a crucial role in the progression of HCC in an integrin β1-dependent manner.
Supporting Evidence
- CD151 was identified as a key molecule involved in the invasion and metastasis of HCC.
- HCC patients with high expression of the CD151/integrin β1 complex had the poorest prognosis.
- Disruption of the CD151/integrin β1 complex significantly impaired cell migration and invasiveness.
- Integrin β1 was found to be a crucial partner in the tetraspanin network centered on CD151.
- Mass spectrometry identified 58 proteins associated with the CD151 complex.
Takeaway
This study found that a protein called CD151 helps cancer cells move and spread in the liver, especially when it works with another protein called integrin β1.
Methodology
The study used immunoprecipitation and mass spectrometry to analyze protein interactions in HCC cells.
Potential Biases
Potential biases may arise from the selection of cell lines and the specific experimental conditions used.
Limitations
The study primarily focuses on in vitro and in vivo models, which may not fully replicate human disease complexity.
Participant Demographics
The study involved 301 patients with hepatocellular carcinoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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