Low Levels of Serum Paraoxonase Activities and Metabolic Syndrome's Impact on Coronary Artery Disease Risk
Author Information
Author(s): Martinelli Nicola, Micaglio Roberta, Consoli Letizia, Guarini Patrizia, Grison Elisa, Pizzolo Francesca, Friso Simonetta, Trabetti Elisabetta, Pignatti Pier Franco, Corrocher Roberto, Olivieri Oliviero, Girelli Domenico
Primary Institution: University of Verona
Hypothesis
Low paraoxonase (PON1) activities are characteristic of metabolic syndrome and may influence the risk of coronary artery disease.
Conclusion
The study found that low PON1 concentrations are typical in metabolic syndrome and may modulate the risk of coronary artery disease.
Supporting Evidence
- Subjects with metabolic syndrome had lower PON1 activities.
- Low DEPCyMCase activity was significantly associated with increased coronary artery disease risk.
- DEPCyMCase activity remained a significant predictor of metabolic syndrome independent of HDL levels.
Takeaway
People with metabolic syndrome have lower levels of a protective enzyme called paraoxonase, which may increase their risk of heart disease.
Methodology
The study evaluated PON1 activities in 293 subjects with or without metabolic syndrome and coronary artery disease using various biochemical assays.
Potential Biases
Potential bias due to the retrospective nature of the study and the small number of enrolled subjects.
Limitations
The study's retrospective design, small sample size, and lack of some clinical data such as waist circumference are limitations.
Participant Demographics
Participants were from Northern Italy, with a mix of those diagnosed with metabolic syndrome and coronary artery disease.
Statistical Information
P-Value
1.58 × 10−5
Confidence Interval
95% CI 1.44–13.10
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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