Nogo Receptor's Role in Dendritic Cell Adhesion to Myelin
Author Information
Author(s): Claire L. McDonald, Karin Steinbach, Florian Kern, Rüdiger Schweigreiter, Roland Martin, Christine E. Bandtlow, Markus Reindl
Primary Institution: Innsbruck Medical University
Hypothesis
The study investigates how Nogo receptors NgR1 and NgR2 affect the adhesion of dendritic cells to myelin.
Conclusion
The absence of NgR1 and NgR2 enhances the adhesion of dendritic cells to myelin, which may have implications for neuroinflammatory disorders.
Supporting Evidence
- Human immature dendritic cells express NgR1 and NgR2, which are down-regulated upon maturation.
- Mature dendritic cells adhere more to myelin than immature dendritic cells.
- Dendritic cells lacking NgR1/2 adhere significantly more to myelin compared to wild type dendritic cells.
Takeaway
When dendritic cells mature, they stick to myelin better because they stop using certain receptors that usually keep them from sticking.
Methodology
Dendritic cells were generated from human blood and mouse bone marrow, and their adhesion to myelin was measured using various assays.
Limitations
The study primarily focuses on in vitro models, which may not fully replicate in vivo conditions.
Participant Demographics
Healthy donors (9) for human DCs; wild type and knockout mice for mouse DCs.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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