Fitness and Mutation Timing Predict Health Outcomes in Clonal Hemopoiesis
Author Information
Author(s): Kirschner Kristina, Cox Simon, Crespo Tamir, Chandra Neil, Robertson Eric, Schumacher Linus
Primary Institution: Mayo Clinic, Rochester, Minnesota, United States
Hypothesis
Fitness and timing of mutations are better predictors of health outcomes in clonal hemopoiesis than clone size.
Conclusion
Fitness and the timing of mutations are better predictors of health outcomes than clone size.
Supporting Evidence
- The prevalence of clonal hematopoiesis increases rapidly from age 60.
- Clonal hematopoiesis is associated with increased risk for malignancy, heart disease, and ischemic stroke.
- Fitness correlates with the timing of mutations in stem cells.
Takeaway
As people age, certain mutations in their blood cells can affect their health, and how fit they are and when these mutations happen can tell us more about their health than just how many mutations they have.
Methodology
The study analyzed fitness effects across three longitudinal cohorts of aging.
Participant Demographics
Participants were from three longitudinal cohorts of aging, totaling 713 individuals.
Digital Object Identifier (DOI)
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