Risk Factors for Local Recurrence in Low Rectal Cancer
Author Information
Author(s): Kozu Takumi, Akiyoshi Takashi, Sakamoto Takashi, Yamaguchi Tomohiro, Yamamoto Seiichiro, Okamura Ryosuke, Konishi Tsuyoshi, Umemoto Yoshihisa, Hida Koya, Naitoh Takeshi
Primary Institution: Japanese Foundation for Cancer Research
Hypothesis
What are the risk factors for local recurrence in patients with clinical stage II/III low rectal cancer?
Conclusion
The study identified several risk factors for local recurrence in low rectal cancer, emphasizing the need for treatment optimization.
Supporting Evidence
- The 5-year cumulative incidence of local recurrence was 12.3%.
- Patients without neoadjuvant treatment had a significantly higher risk of local recurrence.
- BMI ≥25 kg/m2 was associated with an increased risk of local recurrence.
Takeaway
Doctors looked at many patients with low rectal cancer to find out what makes the cancer come back after treatment. They found that certain health factors can make this more likely.
Methodology
Data from 1479 patients treated for low rectal cancer were analyzed using Fine–Gray multivariable regression modeling to identify risk factors for local recurrence.
Potential Biases
The study's retrospective nature may introduce selection bias.
Limitations
The study is retrospective and may be influenced by selection bias and potential confounding factors.
Participant Demographics
The cohort included 68.9% male patients with a median age of 64 years.
Statistical Information
P-Value
<0.05
Confidence Interval
95% CI, 10.7–14.1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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