Effects of Whole Mushrooms on Inflammation
Author Information
Author(s): Yu Sanhong, Weaver Veronika, Martin Keith, Cantorna Margherita T
Primary Institution: The Pennsylvania State University
Hypothesis
Do whole mushrooms stimulate the immune system in vitro and in vivo?
Conclusion
Whole mushrooms can modestly regulate immunity and provide some protection against colonic injury during inflammation.
Supporting Evidence
- White button mushroom extracts stimulated TNF-α production in macrophages.
- Mice fed 2% white button mushrooms showed protection from DSS-induced colonic injury.
- Whole mushrooms had no significant adverse effects on body weight or organ pathology.
Takeaway
Eating mushrooms can help your body fight off sickness, but they don't make a big difference unless you're already sick.
Methodology
Mice were fed diets containing 1-2% whole mushrooms and then tested for immune responses and cytokine production.
Limitations
Results may only reflect mushrooms grown in Pennsylvania and may not apply to mushrooms from other regions.
Participant Demographics
C57BL/6 mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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