Exercise Training and Cardiac Function in Type 2 Diabetic Patients
Author Information
Author(s): Vera B Schrauwen-Hinderling, Ruth Meex, Matthijs K C Hesselink, Tineke van de Weijer, Tim Leiner, Michael Schär, Hildo J Lamb, Joachim E Wildberger, Jan F Glatz, Patrick Schrauwen, M Eline Kooi
Primary Institution: Maastricht University Medical Center
Hypothesis
Can exercise training lower cardiac lipid content and improve cardiac function in type 2 diabetic patients?
Conclusion
Twelve weeks of exercise training improved cardiac function in type 2 diabetic patients without changing cardiac lipid content.
Supporting Evidence
- VO2max increased from 27.1 to 30.1 ml/min/kg.
- Insulin sensitivity improved from 5.8 to 10.3 μmol/kg/min.
- Ejection fraction improved from 50.5% to 55.6%.
- Cardiac lipid content remained unchanged from 0.80% to 0.95%.
Takeaway
This study shows that even if the fat in the heart doesn't go down, exercise can still make the heart work better in people with diabetes.
Methodology
Eleven overweight-to-obese male patients with type 2 diabetes underwent a 12-week exercise program, measuring VO2max, insulin sensitivity, and cardiac function before and after training.
Limitations
The study had a small sample size of only 11 patients.
Participant Demographics
Eleven overweight-to-obese male patients with type 2 diabetes, average age 58.4 years.
Statistical Information
P-Value
p = 0.001 for VO2max, p = 0.02 for insulin sensitivity, p = 0.01 for ejection fraction, p = 0.15 for cardiac lipid content.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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