Pathogenic Bacillus anthracis in the progressive gene losses and gains in adaptive evolution
2009
Evolution of Bacillus anthracis: Gene Losses and Gains
publication
Evidence: moderate
Author Information
Author(s): Yu GX
Primary Institution: Boise State University
Hypothesis
The bacterial pathogen would follow a compatible evolution path.
Conclusion
The study provides new insights into the evolutionary process of Bacillus anthracis, highlighting gene losses and gains that may inform drug and vaccine targets.
Supporting Evidence
- Bacillus anthracis experienced significant gene losses and gains during its evolution.
- The study identified two main evolutionary stages in the adaptation of B. anthracis.
- Gene gains included those related to pathogenic factors such as toxins and surface proteins.
Takeaway
Bacillus anthracis changed a lot over time, losing some genes and gaining others, which helped it become a dangerous pathogen.
Methodology
A cluster-based evolution scheme was devised to analyze genes gained or lost from B. anthracis using comparative genomic analysis.
Limitations
The results can be compromised if homologous genes exist within the target genomes.
Digital Object Identifier (DOI)
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