Genetic Variants Linked to Heart Problems After Bypass Surgery
Author Information
Author(s): Amanda A. Fox, Mias Pretorius, Kuang-Yu Liu, Charles D. Collard, Tjorvi E. Perry, Stanton K. Shernan, Philip L. De Jager, David A. Hafler, Daniel S. Herman, Steven R. DePalma, Dan M. Roden, Jochen D. Muehlschlegel, Brian S. Donahue, Dawood Darbar, J. G. Seidman, Simon C. Body, Christine E. Seidman
Primary Institution: Brigham and Women's Hospital, Harvard Medical School
Hypothesis
Common genetic variants contribute to the development of postoperative ventricular dysfunction (VnD) after CABG surgery.
Conclusion
Three genetic loci were identified that are modestly associated with the risk of developing postoperative ventricular dysfunction after CABG surgery.
Supporting Evidence
- Postoperative ventricular dysfunction occurs in 9-20% of CABG patients.
- Over 100 SNPs were associated with VnD with P<10−4.
- Three SNPs were identified that were more modestly associated with VnD after adjusting for clinical risk factors.
Takeaway
Some people have genes that make them more likely to have heart problems after heart surgery. Finding these genes can help doctors take better care of patients.
Methodology
A genome-wide association study (GWAS) was conducted to identify SNPs associated with postoperative VnD in male subjects of European ancestry undergoing isolated primary CABG surgery.
Potential Biases
Potential bias due to the exclusion of women and non-European ancestry subjects, which limits the diversity of the study population.
Limitations
The study had a small sample size and was limited to male subjects of European ancestry, which may affect the generalizability of the findings.
Participant Demographics
Male subjects of European ancestry undergoing primary CABG surgery.
Statistical Information
P-Value
0.0002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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