Serum Leptin Levels in Normal Pregnancy and Preeclampsia
Author Information
Author(s): Attila Molvarec, András Szarka, Szilvia Walentin, Gabriella Bekő, István Karádi, Zoltán Prohászka, János Rigó Jr
Primary Institution: Semmelweis University, Budapest, Hungary
Hypothesis
This study investigates the relationship between serum leptin levels and various clinical and laboratory parameters in healthy and preeclamptic women.
Conclusion
The study found that elevated serum leptin levels are associated with systemic inflammation and may contribute to the risk of preeclampsia.
Supporting Evidence
- Serum leptin levels were significantly higher in preeclamptic patients and healthy pregnant women than in healthy non-pregnant women.
- Leptin levels correlated positively with BMI and CRP in healthy pregnant women.
- Elevated leptin levels were associated with increased risk of preeclampsia when combined with sFlt-1/PlGF ratio.
Takeaway
The study looked at how leptin levels in pregnant women relate to their health and found that higher leptin levels might be linked to pregnancy complications like preeclampsia.
Methodology
A case-control study involving 60 preeclamptic patients, 60 healthy pregnant women, and 59 healthy non-pregnant women, measuring various serum levels using ELISA and multiplex suspension array.
Limitations
The relatively small sample size may limit the ability to detect effects in subgroup analyses.
Participant Demographics
All participants were Caucasian women from the same geographic area in Hungary.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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