Antagonism of Innate Immunity by Paramyxovirus Accessory Proteins
2009
How Paramyxoviruses Evade the Immune System
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Raychel Chambers, Toru Takimoto
Primary Institution: University of Rochester Medical Center
Hypothesis
Paramyxoviruses use accessory proteins to antagonize innate immunity and affect their pathogenicity.
Conclusion
Paramyxoviruses employ various strategies to inhibit the interferon response, which is crucial for their pathogenicity and host range.
Supporting Evidence
- Paramyxoviruses can block the production of interferons, which are crucial for the immune response.
- Accessory proteins from paramyxoviruses can inhibit the signaling pathways that would normally activate immune defenses.
- Different paramyxoviruses have evolved unique strategies to evade the immune system.
Takeaway
Paramyxoviruses are sneaky viruses that have special tools to trick our immune system so they can grow and spread better.
Methodology
This review summarizes the mechanisms by which paramyxovirus accessory proteins inhibit the innate immune response.
Limitations
The review does not provide experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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