Treatment of Steroid and Cyclosporine-Resistant Nephrotic Syndrome in Children
Author Information
Author(s): Nikibakhsh A. A., Mahmoodzadeh H., Karamyyar M., Hejazi S., Noroozi M., Macooie A. A.
Primary Institution: Urology-Nephrology and Transplantation Research Centre, Department of Paediatric Nephrology, Urmia University School of Medicine, Iran
Hypothesis
Can a two-step treatment protocol effectively induce remission in children with steroid and cyclosporine-resistant nephrotic syndrome?
Conclusion
The combination of mycophenolate mofetil with cyclosporine A induced remission in nearly half of the children with steroid and cyclosporine-resistant nephrotic syndrome.
Supporting Evidence
- Thirty-seven children with steroid-resistant nephrotic syndrome were treated with cyclosporine A and prednisolone.
- Twelve patients (32.4%) achieved complete remission after the first treatment step.
- In the second treatment step, 11 out of 23 children (47.82%) achieved complete remission.
Takeaway
Doctors treated kids with a tough kidney problem using two different medicines, and many of them got better.
Methodology
Children with steroid-resistant nephrotic syndrome were treated with cyclosporine A and prednisolone for 6 months, followed by mycophenolate mofetil if they did not respond.
Potential Biases
Potential bias due to loss of follow-up in some cases.
Limitations
The study lacked immunofluorescence and electron microscopy findings in kidney biopsies.
Participant Demographics
The study included 90 children, with 34.4% female and a mean age of 7.2 years.
Statistical Information
P-Value
0.021
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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