Effects of Tamoxifen and Flaxseed on Breast Tissue Angiogenesis
Author Information
Author(s): Nilsson Åberg Ulrika W., Saarinen Niina, Abrahamsson Annelie, Nurmi Tarja, Engblom Sofia, Dabrosin Charlotta
Primary Institution: Linköping University
Hypothesis
Does tamoxifen or dietary flaxseed affect angiogenesis regulators in normal human breast tissue?
Conclusion
Tamoxifen decreases pro-angiogenic factors and increases the anti-angiogenic factor endostatin in normal breast tissue, while flaxseed has limited effects.
Supporting Evidence
- Tamoxifen decreased levels of VEGF and angiogenin while increasing endostatin.
- Flaxseed did not significantly alter VEGF or angiogenin levels but increased endostatin.
- Estradiol levels correlated positively with VEGF and angiogenin in breast tissue.
Takeaway
This study looked at how tamoxifen and flaxseed affect substances in breast tissue that help control blood vessel growth, finding that tamoxifen works better than flaxseed.
Methodology
Microdialysis was used to sample extracellular proteins in breast tissue before and after treatment with tamoxifen or flaxseed.
Potential Biases
Potential bias due to the lack of randomization in participant selection.
Limitations
The study was limited to a small sample size and short duration of flaxseed supplementation.
Participant Demographics
36 women, including pre-menopausal and post-menopausal individuals, with a range of ages and body mass indices.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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