Using TDAE to Reduce Arenediazonium Salts for Aryl Radical Formation
Author Information
Author(s): Mahesh Mohan, Murphy John A, LeStrat Franck, Wessel Hans Peter
Primary Institution: University of Strathclyde
Hypothesis
Can tetrakis(dimethylamino)ethylene (TDAE) effectively reduce arenediazonium salts to generate aryl radicals?
Conclusion
TDAE is an effective reagent for the reduction of arenediazonium salts, leading to the formation of aryl radicals that can be used to synthesize indolines and indoles.
Supporting Evidence
- TDAE was used for the first time as a mild reagent for the reduction of arenediazonium salts.
- The methodology allows for the efficient synthesis of indolines and indoles.
- The oxidized by-products of TDAE are easily removed from the reaction mixture.
Takeaway
This study shows that a special chemical called TDAE can help make new types of molecules by changing another type of molecule called arenediazonium salts.
Methodology
The study involved using TDAE to reduce arenediazonium salts and observing the resulting products through various chemical reactions.
Limitations
The yields of the products were not high, indicating potential inefficiencies in the radical processes.
Digital Object Identifier (DOI)
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