Rapid Analysis of Pharmacology for Infectious Diseases
Author Information
Author(s): Andrew L. Hopkins, G. Richard Bickerton, Ian M. Carruthers, Stephen K. Boyer, Harvey Rubin, John P. Overington
Primary Institution: University of Dundee
Hypothesis
How do we rapidly and cost-effectively identify potential pharmacological interventions to treat infections?
Conclusion
The study outlines a strategy to leverage genome data and informatics to accelerate drug discovery for infectious diseases.
Supporting Evidence
- Neglected infectious diseases disproportionately affect the poorest populations.
- Only thirteen new drugs were approved for tropical diseases between 1975 and 1999.
- The study emphasizes the need for innovative drug discovery methods to address global health challenges.
Takeaway
This study is about finding new ways to quickly discover medicines for diseases that affect many people, especially in poorer countries.
Methodology
The study discusses the use of genome sequencing and informatics to identify drug targets and prioritize pharmacological experiments.
Limitations
The study acknowledges the current productivity paradox in drug discovery and the challenges in translating genomic data into effective therapies.
Digital Object Identifier (DOI)
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