Posttranslational regulation of Fas ligand function
2008
Regulation of Fas Ligand Function
publication
Evidence: moderate
Author Information
Author(s): Matthias Voss, Marcus Lettau, Maren Paulsen, Ottmar Janssen
Primary Institution: Molecular Immunology, Institute of Immunology, Medical Center Schleswig-Holstein Campus Kiel
Hypothesis
How do posttranslational modifications of Fas ligand relate to its biological functions?
Conclusion
Fas ligand is a crucial death factor in the immune system, and its function is tightly regulated by various posttranslational modifications.
Supporting Evidence
- Fas ligand is involved in immune cell functions and can induce cell death.
- Posttranslational modifications like phosphorylation and ubiquitylation regulate Fas ligand activity.
- Fas ligand's expression is tightly controlled to prevent damage to healthy cells.
Takeaway
Fas ligand helps our immune system kill bad cells, but it needs to be carefully controlled to avoid harming healthy cells.
Methodology
The review discusses various posttranslational modifications and their effects on Fas ligand function.
Digital Object Identifier (DOI)
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