Comparison of Vascular Changes in an Alzheimer's Disease Model and Human Brain
Author Information
Author(s): Nattinee Jantaratnotai, Ryu Jae K., Schwab Claudia, McGeer Patrick L., McLarnon James G.
Primary Institution: The University of British Columbia
Hypothesis
The study aims to compare vascular perturbations in an Aβ-injected animal model with those in human Alzheimer's disease brain tissue.
Conclusion
The study found that the Aβ-injected animal model exhibits similar microvessel abnormalities to those observed in Alzheimer's disease brain tissue.
Supporting Evidence
- Aβ1-42 injection increased the number of microvessels in the rat model.
- Microvessels in AD brain showed significant morphological abnormalities.
- Constricted microvessels were more prevalent in AD compared to ND tissue.
- The study provides evidence of vascular changes in both the animal model and human AD brain.
- Microvessel density was significantly higher in AD brain compared to ND brain.
Takeaway
Researchers injected a special protein into rats to see how it affected their brain blood vessels, and found that it caused changes similar to those seen in people with Alzheimer's disease.
Methodology
The study involved intrahippocampal injection of Aβ1-42 in rats and comparison of microvessel properties with human AD and ND brain tissue.
Potential Biases
Potential bias in interpreting results due to the reliance on animal models for human disease.
Limitations
The study primarily focused on a specific animal model and may not fully represent human conditions.
Participant Demographics
9 non-demented (ND) cases aged 75-99 and 9 Alzheimer's disease (AD) cases aged 65-90.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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