Antibiotic Resistance Trends in France (1996-1998)
Author Information
Author(s): Helene Aubry-Damon, Patrice Courvalin
Primary Institution: Institut de Veille Sanitaire, Saint-Maurice, France; Centre National de Reference des Antibiotiques, Institut Pasteur, Paris, France
Hypothesis
What are the trends in antibiotic resistance among various bacterial pathogens in France?
Conclusion
Antibiotic resistance trends in France are similar to those in other European countries, with some unique characteristics.
Supporting Evidence
- Resistance of E. coli to amoxicillin was 47%.
- MRSA incidence decreased from 42% in 1992 to 37% in 1997.
- Penicillin resistance in S. pneumoniae increased from 3.8% in 1987 to 48% in 1997.
- Fluoroquinolone resistance in C. jejuni increased from 7.4% to 32% between 1993 and 1997.
- Only 0.2% of enterococcal clinical isolates were glycopeptide-resistant.
Takeaway
This study looked at how bacteria in France are becoming resistant to antibiotics, which is a big problem for health.
Methodology
A multicenter study analyzed antibiotic susceptibility of enterobacteria from various hospitals in France.
Potential Biases
Data may be influenced by regional variations and the involvement of the pharmaceutical industry.
Limitations
The representativeness of the data has not been assessed, and the clinical importance of the raw data remains unclear.
Participant Demographics
Isolates were primarily from inpatients (86%) in various hospital units.
Statistical Information
Confidence Interval
95% CI 11.5-17.6 for clarithromycin resistance in H. pylori.
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