Successful Kidney Re-Transplantation Despite Pre-Existing Antibodies
Author Information
Author(s): Hartono John, Lavingia Bhavna, Stastny Peter, Senitko Martin, Vazquez Miguel, Arenas Juan, Lu Christopher
Primary Institution: University of Texas Southwestern Medical Center
Hypothesis
Can kidney transplantation be successful in patients with pre-existing anti-donor DQ5 antibodies?
Conclusion
Transplantation can be successful even when the recipient has pre-existing antibodies against the donor's human leukocyte antigen DQ5.
Supporting Evidence
- The patient had excellent allograft function two years after the second transplant.
- No plasmapheresis or intravenous immunoglobulin was necessary for the patient.
- The patient was matched at Class I HLA A, B, and C.
Takeaway
A man got a new kidney even though he had some antibodies that usually cause problems. It worked well for him!
Methodology
The patient underwent a second kidney transplant with a zero mismatch at Class I HLA, despite having pre-existing anti-DQ5 antibodies.
Limitations
The study is based on a single case, limiting generalizability.
Participant Demographics
Caucasian male, 34 years old at first transplant.
Digital Object Identifier (DOI)
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