Effects of Calorie Restriction and Resveratrol on Obesity and Fatty Liver
Author Information
Author(s): Eveliina Tauriainen, Mira Luostarinen, Essi Martonen, Piet Finckenberg, Miia Kovalainen, Anne Huotari, Karl-Heinz Herzig, Anne Lecklin, Eero Mervaala
Primary Institution: University of Helsinki
Hypothesis
Can resveratrol mimic the beneficial effects of calorie restriction on diet-induced obesity and fatty liver formation?
Conclusion
Calorie restriction provides superior protection against diet-induced obesity and fatty liver compared to resveratrol supplementation.
Supporting Evidence
- Calorie restriction significantly reduced body weight and fat compared to high-fat diet groups.
- Resveratrol did not significantly affect body weight or fat percentage in mice.
- Calorie restriction increased physical activity levels in mice.
Takeaway
Eating less food can help prevent weight gain and liver problems better than taking a supplement called resveratrol.
Methodology
C57Bl/6J mice were divided into groups receiving different diets, including calorie restriction and resveratrol, for 15 weeks, with various measurements taken.
Potential Biases
Potential bias in the interpretation of results due to the controlled laboratory setting.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
Seven-week-old male C57Bl/6J mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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