Ascl1's Role in Gsx Gene Function in Mouse Brain Development
Author Information
Author(s): Wang Bei, Waclaw Ronald R, Allen Zegary J II, Guillemot Francois, Campbell Kenneth
Primary Institution: Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
Hypothesis
Ascl1 plays a critical role in the recovery of striatal development in Gsx2 mutants.
Conclusion
Ascl1 is essential for the Gsx1-mediated recovery of striatal development in Gsx2 mutants.
Supporting Evidence
- Gsx1 can partially compensate for the loss of Gsx2 in the development of striatal projection neurons.
- Ascl1 is required for the Gsx1-mediated recovery in a subset of LGE progenitors.
- Notch signaling is improved in Gsx2;Ascl1 double mutants despite being disrupted in Ascl1 mutants.
Takeaway
This study shows that a gene called Ascl1 helps another gene, Gsx1, to fix problems in brain development when Gsx2 is missing.
Methodology
The study involved generating and analyzing Gsx2EGFP mice and Gsx2;Ascl1 double mutants at multiple embryonic stages.
Limitations
The study primarily focuses on embryonic stages and may not fully capture postnatal effects.
Digital Object Identifier (DOI)
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