Changes in Treatment for Small-Cell Lung Cancer Over 8 Years
Author Information
Author(s): Loaie M. El-Helw, Trevor K. Rogers, Matthew Q. F. Hatton
Primary Institution: Doncaster and Bassetlaw Hospitals NHS Foundation Trust
Hypothesis
What changes in treatment practices for small-cell lung cancer have occurred over an 8-year period?
Conclusion
There has not been any significant improvement in outcomes for patients with small-cell lung cancer despite changes in treatment practices.
Supporting Evidence
- 112 patients had limited disease at presentation.
- 77% of patients treated with chemotherapy had a documented radiological response.
- The median survival for patients with limited disease was 8 months.
Takeaway
Doctors looked at how they treated small-cell lung cancer over 8 years and found that even though they changed their methods, patients didn't live longer.
Methodology
The study used a database to track treatment and outcomes of patients with small-cell lung cancer from 1998 to 2005.
Potential Biases
The patient population may differ from those in clinical trials, potentially affecting outcome comparisons.
Limitations
The study did not document significant improvements in patient outcomes despite changes in treatment practices.
Participant Demographics
235 patients, 51% female, median age 66 years, with 35% aged 70 or older.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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