Risks of Pregnancy Complications After Cervical Cancer Treatment
Author Information
Author(s): Arbyn M, Kyrgiou M, Simoens C, Raifu A O, Koliopoulos G, Martin-Hirsch P, Prendiville W, Paraskevaidis E
Primary Institution: Scientific Institute of Public Health, Brussels, Belgium
Hypothesis
What is the relative risk of perinatal mortality and other severe pregnancy outcomes associated with treatment for cervical intraepithelial neoplasia?
Conclusion
Cold knife conisation and possibly laser conisation and radical diathermy are linked to higher risks of perinatal mortality and severe pregnancy outcomes, while large loop excision does not significantly increase these risks.
Supporting Evidence
- Cold knife conisation was associated with a relative risk of 2.87 for perinatal mortality.
- Severe preterm delivery risk was 2.78 times higher after cold knife conisation.
- Laser conisation showed increased risk for low birth weight.
- Large loop excision did not significantly increase risks of severe pregnancy outcomes.
- Diathermy was linked to higher rates of perinatal mortality and low birth weight.
Takeaway
Women who have had certain treatments for cervical cancer may have a higher chance of problems during pregnancy, like losing the baby or having a very early delivery.
Methodology
Meta-analysis of studies comparing pregnancy outcomes in women treated for cervical intraepithelial neoplasia versus untreated women.
Potential Biases
Selection bias may exist due to non-randomized control groups.
Limitations
The studies included were mostly retrospective, which may introduce bias.
Participant Demographics
Women treated for cervical intraepithelial neoplasia, primarily aged around 30.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.42 to 5.81
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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