How PSMA Affects IL-6 and CCL5 in Prostate Cancer Cells
Author Information
Author(s): Colombatti Marco, Grasso Silvia, Porzia Alessandra, Fracasso Giulio, Scupoli Maria Teresa, Cingarlini Sara, Poffe Ornella, Naim Hassan Y., Heine Martin, Tridente Giuseppe, Mainiero Fabrizio, Ramarli Dunia
Primary Institution: Department of Pathology, University of Verona, Verona, Italy
Hypothesis
PSMA could be endowed with signalling properties and that its stimulation might impact on the regulation of the gene expression of IL-6 and CCL5.
Conclusion
PSMA activation leads to increased expression of IL-6 and CCL5 in prostate cancer cells, which may contribute to tumor growth and survival.
Supporting Evidence
- PSMA cross-linking activates RAS and RAC1, leading to MAPK pathway activation.
- Increased IL-6 and CCL5 production was observed following PSMA activation.
- Pharmacological inhibitors showed that p38 plays a major role in IL-6 and CCL5 expression.
Takeaway
PSMA helps prostate cancer cells grow by making them produce more of a substance called IL-6 and CCL5, which helps them survive and multiply.
Methodology
The study used LNCaP prostate cancer cells to investigate the effects of PSMA cross-linking on IL-6 and CCL5 expression through MAPK pathway activation.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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