Lung Function Testing in Infants with Aortic Arch Anomalies
Author Information
Author(s): Roehr Charles Christoph, Wilitzki Silke, Opgen-Rhein Bernd, Kalache Karim, Proquitté Hans, Bührer Christoph, Schmalisch Gerd
Primary Institution: Charité Universitätsmedizin Berlin
Hypothesis
Lung function testing in the neonatal period allows the identification and monitoring of patients with aortic arch anomalies.
Conclusion
Both infants with right-sided and double-sided aortic arch anomalies are at risk for airway obstruction, and early lung function testing helps to identify and monitor these infants.
Supporting Evidence
- Infants with double-sided aortic arch anomalies had significantly more expiratory flow limitations compared to those with right-sided anomalies.
- 24% of infants were near or below the 10th percentile of V′maxFRC, indicating a high risk for airway obstruction.
- The study is the largest aggregation of early, pre-surgical lung function testing of infants with aortic arch anomalies.
Takeaway
Doctors can check how well babies breathe to see if they might have problems with their airways because of heart issues.
Methodology
The study involved neonatal lung function testing on 17 infants with aortic arch anomalies, measuring various lung function parameters.
Potential Biases
The study may have bias due to the retrospective nature and the limited number of measurements available for subgroup comparisons.
Limitations
The small sample size limits statistical power and increases the risk of type II error.
Participant Demographics
17 infants with aortic arch anomalies (10 with right-sided and 7 with double-sided anomalies).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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