Gold-Catalyzed Ring Expansions in Organic Chemistry
Author Information
Author(s): David Garayalde, Christina Nevado
Primary Institution: University of Zürich
Hypothesis
The development of new methodologies catalyzed by late transition metals involving cycloisomerizations of strained rings can open new venues for the synthesis of structurally complex molecules.
Conclusion
Gold-catalyzed ring expansions of strained rings are now considered a mature tool for constructing molecular complexity.
Supporting Evidence
- Gold has evolved from being considered unreactive to playing a key role in catalytic processes.
- Gold-catalyzed transformations can activate strained ring systems, opening new research areas.
- Chiral gold catalysts have been developed for highly stereocontrolled transformations.
Takeaway
This study shows how gold can help make complex molecules by expanding small rings in organic chemistry.
Methodology
The review summarizes recent developments in gold-catalyzed ring expansions from both synthetic and mechanistic perspectives.
Limitations
The review does not provide experimental data or specific limitations of the methodologies discussed.
Digital Object Identifier (DOI)
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