PACAP is Implicated in the Stress Axes
2011
PACAP and Its Role in Stress Responses
publication
Evidence: moderate
Author Information
Author(s): Hashimoto Hitoshi, Shintani Norihito, Tanida Mamoru, Hayata Atsuko, Hashimoto Ryota, Baba Akemichi
Primary Institution: Osaka University
Hypothesis
PACAP is an important regulator of stress axes and may influence stress-related psychopathology.
Conclusion
PACAP plays a crucial role in regulating stress responses and may be involved in the development of psychiatric disorders.
Supporting Evidence
- PACAP is required for sustained epinephrine secretion during metabolic stress.
- PACAP-deficient mice show impaired stress responses.
- Chronic stress increases PACAP expression in the brain.
- Altered PACAP signaling may contribute to psychiatric disorders.
Takeaway
PACAP is a special chemical in our body that helps us deal with stress, and it might be linked to feelings of anxiety and depression.
Methodology
The article reviews existing studies on PACAP's role in stress responses and its implications for psychiatric disorders.
Digital Object Identifier (DOI)
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