Study on MAM Granules for Viral Infections
Author Information
Author(s): Verma Dileep Kumar, Hasan Abdul, Rengaraju Manickavasagam, Devi Shree, Sharma Geetika, Narayanan Vimal, Parameswaran Sathiyarajeswaran, Kumar D Thirumal, Kadarkarai Kanakavalli, Sunil Sujatha
Primary Institution: International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
Hypothesis
Can MAM granules effectively modulate immune response and exhibit antiviral properties against SARS-CoV-2 and chikungunya virus?
Conclusion
MAM granules are non-toxic and possess potent antiviral, antioxidant, and anti-inflammatory properties.
Supporting Evidence
- MAM granules showed no significant toxicity in Wistar rats.
- MAM extract reduced viral titers of SARS-CoV-2 and CHIKV in vitro.
- All ingredients of MAM contributed synergistically to its antioxidant activity.
- Withania somnifera exhibited the most potent antioxidant activity among the ingredients.
- MAM extract significantly reduced the production of inflammatory mediators.
Takeaway
MAM granules, made from three herbs, can help fight viruses and reduce inflammation without harming the body.
Methodology
The study involved in vivo toxicity tests on Wistar rats and in vitro assays using cell lines to evaluate antiviral, antioxidant, and anti-inflammatory properties.
Limitations
Further studies are needed to verify the underlying mechanisms of action.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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